Publications
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2024
The computational bottleneck of basal ganglia output (and what to do about it)
Mark D. Humphries
Cold Spring Harbor Laboratory
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24 Oct 2024
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doi:10.1101/2024.10.23.619790
Motor Cortex Latent Dynamics Encode Spatial and Temporal Arm Movement Parameters Independently
Andrea Colins Rodriguez, Matt G. Perich, Lee E. Miller, Mark D. Humphries
The Journal of Neuroscience
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26 Jul 2024
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doi:10.1523/JNEUROSCI.1777-23.2024
Tracking subjects’ strategies in behavioural choice experiments at trial resolution
Silvia Maggi, Rebecca M Hock, Martin O’Neill, Mark Buckley, Paula M Moran, Tobias Bast, Musa Sami, Mark D Humphries
eLife
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01 Mar 2024
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doi:10.7554/eLife.86491
2022
Activity Subspaces in Medial Prefrontal Cortex Distinguish States of the World
Silvia Maggi, Mark D. Humphries
The Journal of Neuroscience
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14 Apr 2022
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doi:10.1523/JNEUROSCI.1412-21.2022
2021
Bayesian Mapping of the Striatal Microcircuit Reveals Robust Asymmetries in the Probabilities and Distances of Connections
François Cinotti, Mark D. Humphries
The Journal of Neuroscience
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10 Dec 2021
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doi:10.1523/jneurosci.1487-21.2021
Making decisions in the dark basement of the brain: A look back at the GPR model of action selection and the basal ganglia
Mark D. Humphries, Kevin Gurney
Biological Cybernetics
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17 Jul 2021
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doi:10.1007/s00422-021-00887-5
Spectral estimation for detecting low-dimensional structure in networks using arbitrary null models
Mark D. Humphries, Javier A. Caballero, Mat Evans, Silvia Maggi, Abhinav Singh
PLOS ONE
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02 Jul 2021
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doi:10.1371/journal.pone.0254057
Strong and weak principles of neural dimension reduction
Mark D Humphries
Neurons, Behavior, Data analysis, and Theory
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17 Jun 2021
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doi:10.51628/001c.24619
The spike: an epic journey through the brain in 2.1 seconds
Mark Humphries
Princeton University Press
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01 Jan 2021
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isbn:9780691195889
2019
On the use of calcium deconvolution algorithms in practical contexts
Mathew H. Evans, Rasmus S. Petersen, Mark D. Humphries
Cold Spring Harbor Laboratory
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11 Dec 2019
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doi:10.1101/871137
Maladaptive striatal plasticity and abnormal reward‐learning in cervical dystonia
Tom Gilbertson, Mark Humphries, J. Douglas Steele
European Journal of Neuroscience
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14 May 2019
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doi:10.1111/ejn.14414
Prediction of Choice from Competing Mechanosensory and Choice-Memory Cues during Active Tactile Decision Making
Dario Campagner, Mathew H. Evans, Katarina Chlebikova, Andrea Colins-Rodriguez, Michaela S.E. Loft, Sarah Fox, David Pettifer, Mark D. Humphries, Karel Svoboda, Rasmus S. Petersen
The Journal of Neuroscience
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08 Mar 2019
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doi:10.1523/JNEUROSCI.2217-18.2019
Medial prefrontal cortex population activity is plastic irrespective of learning
Abhinav Singh, Adrien Peyrache, Mark D. Humphries
The Journal of Neuroscience
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27 Feb 2019
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doi:10.1523/jneurosci.1370-17.2019
2018
An ensemble code in medial prefrontal cortex links prior events to outcomes during learning
Silvia Maggi, Adrien Peyrache, Mark D. Humphries
Nature Communications
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07 Jun 2018
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doi:10.1038/s41467-018-04638-2
Insights into Parkinson’s disease from computational models of the basal ganglia
Mark D Humphries, Jose Angel Obeso, Jakob Kisbye Dreyer
Journal of Neurology, Neurosurgery & Psychiatry
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17 Apr 2018
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doi:10.1136/jnnp-2017-315922
A probabilistic, distributed, recursive mechanism for decision-making in the brain
Javier A. Caballero, Mark D. Humphries, Kevin N. Gurney
PLOS Computational Biology
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03 Apr 2018
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doi:10.1371/journal.pcbi.1006033
2017
Dynamical networks: Finding, measuring, and tracking neural population activity using network science
Mark D. Humphries
Network Neuroscience
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01 Dec 2017
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doi:10.1162/NETN_a_00020
A spiral attractor network drives rhythmic locomotion
Angela M Bruno, William N Frost, Mark D Humphries
eLife
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07 Aug 2017
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doi:10.7554/eLife.27342
2016
The Goldilocks zone in neural circuits
Mark D Humphries
eLife
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02 Dec 2016
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doi:10.7554/eLife.22735
2015
Modular Deconstruction Reveals the Dynamical and Physical Building Blocks of a Locomotion Motor Program
Angela M. Bruno, William N. Frost, Mark D. Humphries
Neuron
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01 Apr 2015
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doi:10.1016/j.neuron.2015.03.005
Finding communities in sparse networks.
Abhinav Singh, Mark D Humphries
Scientific reports
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06 Mar 2015
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pmid:25742951
A new framework for cortico-striatal plasticity: behavioural theory meets in vitro data at the reinforcement-action interface.
Kevin N Gurney, Mark D Humphries, Peter Redgrave
PLoS biology
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06 Jan 2015
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pmid:25562526
2014
Early hypersynchrony in juvenile PINK1(-)/(-) motor cortex is rescued by antidromic stimulation.
Romain Carron, Anton Filipchuk, Romain Nardou, Abhinav Singh, Francois J Michel, Mark D Humphries, Constance Hammond
Frontiers in systems neuroscience
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21 May 2014
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pmid:24904316
Striatal disorders dissociate mechanisms of enhanced and impaired response selection - Evidence from cognitive neurophysiology and computational modelling.
Christian Beste, Mark Humphries, Carsten Saft
NeuroImage. Clinical
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12 Apr 2014
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pmid:24936413
Slaves to the rhythm: coupling of the subthalamic nucleus-globus pallidus network in Parkinsonian oscillations.
Mark D Humphries
The Journal of physiology
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01 Apr 2014
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pmid:24692460
Transient and steady-state selection in the striatal microcircuit.
Adam Tomkins, Eleni Vasilaki, Christian Beste, Kevin Gurney, Mark D Humphries
Frontiers in computational neuroscience
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20 Jan 2014
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pmid:24478684
2013
Population-wide distributions of neural activity during perceptual decision-making
Adrien Wohrer, Mark D. Humphries, Christian K. Machens
Progress in Neurobiology
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01 Apr 2013
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doi:10.1016/j.pneurobio.2012.09.004
Passive Dendrites Enable Single Neurons to Compute Linearly Non-separable Functions
Romain Daniel Cazé, Mark Humphries, Boris Gutkin
PLoS Computational Biology
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28 Feb 2013
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doi:10.1371/journal.pcbi.1002867
2012
Network effects of subthalamic deep brain stimulation drive a unique mixture of responses in basal ganglia output
Mark D. Humphries, Kevin Gurney
European Journal of Neuroscience
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01 Jul 2012
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doi:10.1111/j.1460-9568.2012.08085.x
Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia.
Mark D Humphries, Mehdi Khamassi, Kevin Gurney
Frontiers in neuroscience
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06 Feb 2012
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pmid:22347155
Integrating cortico-limbic-basal ganglia architectures for learning model-based and model-free navigation strategies
Mehdi Khamassi, Mark D. Humphries
Frontiers in Behavioral Neuroscience
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01 Jan 2012
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doi:10.3389/fnbeh.2012.00079
Dopaminergic control of the exploration-exploitation trade-off via the basal ganglia
Mark Humphries
Frontiers in Neuroscience
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01 Jan 2012
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doi:10.3389/fnins.2012.00009
2011
The medial reticular formation: a brainstem substrate for simple action selection?
Mark D. Humphries, Kevin N. Gurney, Tony J Prescott
Modelling Natural Action Selection
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10 Nov 2011
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doi:10.1017/CBO9780511731525.018
Spike-Train Communities: Finding Groups of Similar Spike Trains
Mark D. Humphries
The Journal of Neuroscience
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09 Feb 2011
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doi:10.1523/JNEUROSCI.2853-10.2011
Onset of pup locomotion coincides with loss of NR2C/D-mediated cortico-striatal EPSCs and dampening of striatal network immature activity
Nathalie Dehorter
Frontiers in Cellular Neuroscience
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01 Jan 2011
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doi:10.3389/fncel.2011.00024
2010
Reconstructing the Three-Dimensional GABAergic Microcircuit of the Striatum
Mark D. Humphries, Ric Wood, Kevin Gurney
PLoS Computational Biology
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24 Nov 2010
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doi:10.1371/journal.pcbi.1001011
The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.
Mark D. Humphries, Tony J. Prescott
Progress in Neurobiology
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01 Apr 2010
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doi:10.1016/j.pneurobio.2009.11.003
2009
Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit
Mark D. Humphries, Ric Wood, Kevin Gurney
Neural Networks
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01 Oct 2009
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doi:10.1016/j.neunet.2009.07.018
Technical integration of hippocampus, basal ganglia and physical models for spatial navigation
Charles Fox
Frontiers in Neuroinformatics
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01 Jan 2009
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doi:10.3389/neuro.11.006.2009
Capturing dopaminergic modulation and bimodal membrane behaviour of striatal medium spiny neurons in accurate, reduced models
Mark Humphries
Frontiers in Computational Neuroscience
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01 Jan 2009
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doi:10.3389/neuro.10.026.2009
2008
Network ‘Small-World-Ness’: A Quantitative Method for Determining Canonical Network Equivalence
Mark D. Humphries, Kevin Gurney
PLoS ONE
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30 Apr 2008
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doi:10.1371/journal.pone.0002051
2007
Solution Methods for a New Class of Simple Model Neurons
Mark D. Humphries, Kevin Gurney
Neural Computation
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01 Dec 2007
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doi:10.1162/neco.2007.19.12.3216
Is there a brainstem substrate for action selection?
M D Humphries, K Gurney, T J Prescott
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
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29 Sep 2007
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pmid:17428776
2006
A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia
Mark D. Humphries, Robert D. Stewart, Kevin N. Gurney
The Journal of Neuroscience
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13 Dec 2006
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doi:10.1523/JNEUROSCI.3486-06.2006
The brainstem reticular formation is a small-world, not scale-free, network.
M D Humphries, K Gurney, T J Prescott
Proceedings. Biological sciences
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22 Feb 2006
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pmid:16615219
A robot model of the basal ganglia: Behavior and intrinsic processing
Tony J. Prescott, Fernando M. Montes González, Kevin Gurney, Mark D. Humphries, Peter Redgrave
Neural Networks
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01 Jan 2006
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doi:10.1016/j.neunet.2005.06.049
2002
The role of intra-thalamic and thalamocortical circuits in action selection
M.D. Humphries, K.N. Gurney
Network: Computation in Neural Systems
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01 Jan 2002
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doi:10.1088/0954-898X/13/1/305
2001
A pulsed neural network model of bursting in the basal ganglia
Mark D. Humphries, Kevin N. Gurney
Neural Networks
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01 Jul 2001
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doi:10.1016/S0893-6080(01)00060-0